Herbert Chen Selected Research

N- (5- (3- dimethylaminobenzamido)- 2- methylphenyl)- 4- hydroxybenzamide

6/2010	ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.
5/2008	ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.
12/2007	Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.
6/2006	ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.
2/2006	The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors?
6/2005	ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.

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Herbert Chen Research Topics

Disease

106	Neoplasms (Cancer) 12/2021 - 04/2002
51	Primary Hyperparathyroidism 03/2022 - 08/2002
38	Carcinoid Tumor (Carcinoid) 12/2020 - 12/2002
34	Neuroendocrine Tumors (Neuroendocrine Tumor) 12/2021 - 12/2003
34	Thyroid Neoplasms (Thyroid Cancer) 11/2020 - 01/2004
33	Hyperparathyroidism 01/2022 - 05/2002
24	medullary Thyroid cancer 12/2020 - 12/2003
16	Adenoma (Adenomas) 01/2022 - 09/2003
13	Neoplasm Metastasis (Metastasis) 11/2019 - 06/2005
12	Papillary Thyroid Cancer 01/2021 - 06/2006
11	Hyperthyroidism 01/2022 - 04/2013
11	Graves Disease (Basedow Disease) 01/2021 - 02/2003
11	Pheochromocytoma 09/2012 - 03/2004
10	Hypocalcemia 01/2022 - 07/2006
10	Anaplastic Thyroid Carcinoma 01/2019 - 09/2011
9	Goiter 01/2020 - 02/2003
9	Parathyroid Neoplasms (Parathyroid Neoplasm) 01/2019 - 08/2002
8	Hypercalcemia (Milk Alkali Syndrome) 01/2022 - 09/2011
8	Hyperplasia 01/2022 - 05/2002
7	Thyroid Diseases (Thyroid Disease) 01/2017 - 12/2006
6	follicular Thyroid cancer 01/2019 - 02/2009
5	Pain (Aches) 01/2022 - 01/2006
5	Secondary Hyperparathyroidism 11/2019 - 05/2003
5	Carcinogenesis 01/2018 - 03/2008
5	Thyroid Nodule (Nodule, Thyroid) 01/2017 - 03/2008
4	Hypoparathyroidism 01/2021 - 09/2010
4	Vitamin D Deficiency 01/2016 - 07/2006
4	Hematoma 01/2016 - 01/2011
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 07/2009 - 02/2006
3	Osteoporosis 01/2021 - 06/2004
3	Carcinoma (Carcinomatosis) 01/2019 - 10/2008
3	Hypothyroidism 01/2017 - 10/2009
2	Nephrolithiasis 01/2021 - 09/2011

Drug/Important Bio-Agent (IBA)

33	Parathyroid Hormone (Parathormone)IBA 01/2021 - 08/2002
22	Hormones (Hormone)IBA 12/2021 - 08/2003
21	CalciumIBA 01/2022 - 07/2006
16	Pharmaceutical PreparationsIBA 10/2020 - 02/2006
16	IodineIBA 01/2019 - 06/2006
14	Histone Deacetylase InhibitorsIBA 01/2020 - 10/2007
14	Chromogranin AIBA 04/2011 - 08/2003
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2002
10	Serotonin (5 Hydroxytryptamine)IBA 01/2013 - 08/2003
8	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2020 - 01/2006
8	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2020 - 11/2012
8	Valproic Acid (Depakote)FDA LinkGeneric 06/2019 - 08/2007
7	Transcription Factors (Transcription Factor)IBA 08/2014 - 12/2003
6	Vitamin D FDA LinkGeneric 01/2022 - 09/2010
6	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2015 - 08/2006
6	Glycogen Synthase (Synthase I)IBA 05/2014 - 03/2007
6	CatecholaminesIBA 09/2012 - 03/2004
6	N- (5- (3- dimethylaminobenzamido)- 2- methylphenyl)- 4- hydroxybenzamideIBA 06/2010 - 06/2005
5	Histone Deacetylases (Histone Deacetylase)IBA 06/2019 - 07/2008
5	thailandepsin AIBA 06/2019 - 07/2014
5	AntibodiesIBA 01/2018 - 09/2011
5	MicellesIBA 02/2017 - 10/2013
5	RacivirIBA 01/2017 - 09/2009
5	Octreotide (Sandostatin)FDA LinkGeneric 06/2016 - 01/2006
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2013 - 08/2003
5	Peptides (Polypeptides)IBA 04/2011 - 06/2006
5	Lithium ChlorideIBA 01/2011 - 02/2007
5	Glycogen Synthase Kinase 3 betaIBA 06/2010 - 02/2007
4	Messenger RNA (mRNA)IBA 01/2020 - 07/2005
4	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2019 - 03/2008
4	Protein Isoforms (Isoforms)IBA 09/2017 - 05/2014
4	ResveratrolIBA 01/2016 - 05/2011
4	Tumor Biomarkers (Tumor Markers)IBA 05/2014 - 12/2008
4	Small Interfering RNA (siRNA)IBA 11/2012 - 08/2007
4	LithiumIBA 01/2011 - 02/2007
4	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 11/2009 - 12/2006
4	Estrogens (Estrogen)FDA Link 08/2006 - 12/2002
3	Immunoconjugates (Immunoconjugate)IBA 01/2021 - 04/2017
3	Indicators and Reagents (Reagents)IBA 01/2020 - 09/2009
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 09/2010
3	Antineoplastic Agents (Antineoplastics)IBA 09/2017 - 11/2007
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 03/2008
3	LigandsIBA 01/2016 - 07/2005
3	Thyroglobulin FDA Link 10/2015 - 03/2014
3	teriflunomideIBA 11/2013 - 02/2010
3	Notch1 ReceptorIBA 02/2013 - 07/2009
3	Phosphotransferases (Kinase)IBA 05/2010 - 12/2006
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2010 - 03/2007
3	Mitogen-Activated Protein KinasesIBA 05/2010 - 12/2006
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2009 - 11/2008
2	somatostatin receptor 2IBA 01/2021 - 01/2020

Therapy/Procedure

78	Parathyroidectomy 03/2022 - 05/2002
59	Thyroidectomy 10/2021 - 11/2002
47	Therapeutics 01/2021 - 06/2006
11	Drug Therapy (Chemotherapy) 01/2018 - 04/2002
6	Adrenalectomy 01/2022 - 06/2004
5	Aftercare (After-Treatment) 01/2020 - 06/2010
5	Kidney Transplantation 01/2016 - 05/2002
5	Lymph Node Excision (Lymph Node Dissection) 12/2014 - 04/2007
5	Operative Time 07/2014 - 10/2003
4	Neck Dissection (Radical Neck Dissection) 01/2021 - 12/2009
3	Operative Surgical Procedures 01/2019 - 08/2010
3	Radiotherapy 01/2016 - 03/2012
3	Palliative Care (Palliative Therapy) 06/2008 - 10/2005
2	Length of Stay 01/2022 - 10/2017
2	Ambulatory Surgical Procedures (Outpatient Surgery) 01/2022 - 01/2014
2	Preoperative Care 01/2020 - 01/2020